Lopez could refer to:
- People
- Lopez (Admiral), a 23rd century Starfleet admiral
- Lopez (Captain), a 24th century Starfleet captain
- Lopez (Ensign), an engineer aboard the USS Enterprise-D
- Lopez (Lieutenant), a security officer aboard the USS Enterprise-E
- Lopez (USS Enterprise), a security officer aboard the USS Enterprise
- Antonio López de Santa Anna, a freedom fighter in Mexico
- Esteban Lopez, a survivor of the Battle of Wolf 359
- Hidalgo Lopez, a retired Starfleet engineer
- Jacqueline Lopez, a 23rd century Starfleet Academy graduate
- Rachel Lopez, an ensign serving aboard the USS Enterprise-D
- Roderigo Lopez, mayor of Lopez City
- Sarah Lopez, an engineer aboard the USS Enterprise
- Locations
- Lopez City, a settlement on the planet of Turningpoint
- Lopez Island, one of the San Juan Islands in the Pacific Ocean
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