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In 2268, when the Medeusan Kollos' mind was temporarily within Spock's body during a Vulcan mind meld, he quoted Byron's 1814 poem, "She Walks in Beauty like the Night," referring to Nyota Uhura. (TOS episode: "Is There in Truth No Beauty?")
In 2373, a holographic simulation of Byron was created by the Doctor aboard the USS Voyager, as part of a study to attempt to expand his personality sub-routines. He discussed the function of sex with Mahatma Gandhi. (VOY episode: "Darkling")