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Lorillian children were weaned off methyl oxide by steadily removing and reattaching a breathing mask in a class M environment, at the approximate age of four. (ENT episode & novelization: Broken Bow)
Lorillians lived in families. Freighter crews were members of a family, similar to Human space boomers. Lorillian families included parents, children and cousins. A mother regarded the father of her child as "breeding partner." The Klingons considered the Lorillians a "weakling race" and regarded them as former jeghpu'wI' of the Vulcans. (ENT - Rise of the Federation novel: Tower of Babel)
In the mid-22nd century, the Lorillians were an independent species conducting trade in the Kandari sector. They had been inside the Vulcan sphere of influence until the founding of the Federation. The Klingon Empire considered them former jeghpu'wI', or clients, of the Confederacy of Vulcan. (ENT episode & novelization: Broken Bow, ENT - Rise of the Federation novel: Tower of Babel)
In April 2151, first contact between Lorillians and Humans occurred when Earth starship Enterprise (NX-01) visited Rigel X. Commander Charles Tucker III encountered a Lorillian mother weaning off her four year old son from methyl oxide. (ENT episode & novelization: Broken Bow)
On November 1st, 2162, Federation President Thomas Vanderbilt was concerned how the Lorillians, Denobulans and Arkenites would take that Federation transporter technology was unsafe for long term usage. Vanderbilt had hoped to advertise the technology to entice the Lorillians to join the young Federation. (ENT - Rise of the Federation novel: A Choice of Futures)
On October 19th, 2163, the Klingon privateer Sud Qav raided a Lorillian freighter in the Kandari sector. When Starfleet vessel USS Pioneer arrived at the scene to lend aid, the Klingons had already left. Fortunately, the Pioneer was able to save four survivors. At this time, the Lorillians were trading and talking with the Federation but not formally aligned. By February 19th, 2164, the Lorillians and the Axanar were pressuring the Rigelian Trade Commission to enact security and anti-piracy laws, or even to join the Federation to gain Starfleet protection in the Kandari sector. (ENT - Rise of the Federation novel: Tower of Babel)