Macaroni and cheese was a type of food in Human culture, consisting of cooked macaroni pasta coated with melted cheese or a cheese sauce.
In 2020, Marcus O'Herlihy offered Alice Fontana a dinner of macaroni and cheese and apple cobbler while they were aboard the USS Lewis & Clark. (TOS novel: The Rings of Time)
Macaroni and cheese was a favorite "comfort food" of Lieutenant Tom Paris and Lieutenant Commander Kieran Duffy. (VOY - String Theory novel: Fusion; SCE - Have Tech, Will Travel eBook: Hard Crash)
Neelix once attempted to make macaroni and cheese for the USS Voyager crew using brill cheese, which released a dangerous microbe into the life support systems. (VOY episode: "Learning Curve")