Mandisa was a rare Orion alcoholic beverage, known for its qualities as an aphrodisiac. Sale of mandisa was illegal in the Federation.

In 2265, when at Starbase 47, which was outside the Federation's borders, Montgomery Scott hoped he could obtain some mandisa from the Orion merchant Ganz. However, he was apparently not the first with this idea, and Ganz threatened to have him pushed out an airlock if he was the next person to ask for mandisa. Scott changed his mind, and was given something "green" instead. (VAN novel: Harbinger)

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