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Marco Polo (or Polo) could refer to:
- Marco Polo (explorer), the Italian explorer
- Polo, a shuttlecraft
- Marco Polo (22nd century), a 22nd century Earth ship
- UNSS Marco Polo, a 22nd century trade vessel
- Marco Polo (freighter), a freighter
- USS Marco Polo (NCC-7219), a variant Constellation-class starship
- USS Marco Polo (Saber class), a Saber-class class starship in the 24th century