Sometime during or prior to the 2350s, she married Robert Picard, and moved with him into his family's estate in La Barre. Together, they had a son, René. Despite the strained relationship between her husband and his younger brother, Jean-Luc Picard, Marie initiated a continuing correspondence with the Starfleet captain to keep him abreast of family matters. However, they did not meet in person until 2367. (TNG episode: "Family")
Marie lost both her husband and son in a house fire in 2371. (TNG movie: Star Trek Generations) She later had the house rebuilt and restored to its former state. (TNG novel: Losing the Peace) She also ensured the winery continued operating, though she found it difficult to hire other experienced vintners. As a result, the Chateau Picard vintage 2372 was considered disappointing, though later vintages showed improvement. (TNG novel: Q & A)
Marie had a niece, Amarante Lebel, who graduated from Starfleet Academy in 2375. Although the two women were not particularly close, Marie urged Jean-Luc to form a relationship with the young woman. (TNG short story: "Eleven Hours Out")
- The TNG novel: Death in Winter stated that Marie perished in the fire along with Robert and René. This point has been disregarded in subsequent stories.