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Matthias W. Jefferies was a human Starfleet flag officer in the 23rd century.
In 2264, Admiral Jefferies served as Chief of Starfleet Operations and authorised the recommissioning of three Daedalus-class starships for use by the Starfleet Corps of Engineers.
He was interviewed about that decision by Federation News Service reporter Tim Pennington. (Star Trek Magazine Issue 162: "Blast Off!")