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In 2275, the Mecufi was deployed to Space Station Sigma One in order to hunt down Andorian scientist Muav Haslev. The Mecufi was unsuccessful at the station and ended up pursuing the USS Enterprise, believing Haslev was aboard. Eventually, the Mecufi and the destroyer Umyfymu engaged the Enterprise in battle, resulting in the Mecufi's destruction. (TOS novel: Death Count)