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In the 23rd century, a deadlier and more virulent strain of myrruthesia struck the Romulan Star Empire and devastated a third of the population who would die within forty-eight hours should a cure not be administered. This nearly brought the Empire and the Federation at war as the Romulan ship Raptor desperately attempted to reach Canara, which was home to a special compound that could synthesize a cure for the disease. (TOS novel: Web of the Romulans)