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Nautilus could refer to:
- Nautilus (mollusk), a type of sea mollusk
- Nautilus (submarine), a submersible used on Timshel in 2267
- Nautilus (amphishuttle), an amphishuttle used on Pacifica in 2310
- USS Nautilus (Constitution-class)
- USS Nautilus (NCC-31910), a Miranda-class ship
- USS Nautilus (Akira-class)
- USS Nautilus (Steamrunner-class)
- Nautilus (26th century), a starship from the 26th century