Neplatrenu was a degenerative disease that afflicted the Payav of planet Mestiko. Neplatrenu was not always fatal, but did take a marked physical toll on its victims, especially the elderly.

Flen etHamwora, First Consul of the nation-state of Gelta and leader of the Zamestaad, was diagnosed with neplatrenu circa 2264, but opted to conceal his illness from the public, a charade that became harder to maintain as the disease progressed. (TOS eBook: Mere Anarchy: Things Fall Apart)