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Neplatrenu was a degenerative disease that afflicted the Payav of planet Mestiko. Neplatrenu was not always fatal, but did take a marked physical toll on its victims, especially the elderly.
Flen etHamwora, first consul of the nation-state of Gelta and leader of the Zamestaad, was diagnosed with neplatrenu circa the year 2264, but opted to conceal his illness from the public, a charade that became harder to maintain as the disease progressed. (TOS - Mere Anarchy eBook: Things Fall Apart)