New Samarkand is the capital city of the Alpha Centauri Concordium, located on the planet Alpha Centauri III. (ENT novel: Kobayashi Maru) It was one of the oldest Human settlements on that planet. (TLE novel: The Buried Age)

New Samarkand is the location of the University of Alpha Centauri. (TLE novel: The Buried Age)

At least two hospitals serve New Samarkand: Our Lady of Significant Mercy Hospital and Archer University Hospital. (ST novel: A Singular Destiny)

Following the Borg Invasion of 2381, riots erupted in New Samarkand, apparently sparked by fighting over medication at Mercy Hospital. (ST novel: A Singular Destiny)

Sabih Ali was from New Samarkand. (DS9 novel: Force and Motion)

The author's annotations for The Buried Age indicate that this city is named for the ancient Central Asian trading center Samarkand.