Nigel Holmes was a male Human in Starfleet in the 24th century.

In 2332, Commander Holmes became first officer of the USS Enterprise-C, under Captain Rachel Garrett. The two became close friends during their service together, though the two never engaged in any romantic activities, as was rumored.

In late 2335 or early 2336, the Enterprise responded to a distress call from a transport ship threatened by Klingon pirates. Holmes volunteered to go aboard the transport vessel, and when the Klingons opened fire, Garrett was forced by regulations to rescue the transport crew ahead of her officer. Holmes was killed in the attack, and Garrett carried the guilt for his death for several months after.

Holmes was succeeded as first officer by Commander Samir al-Halak. (TLE novel: Well of Souls)

USS Enterprise-C personnel
	Alfonzo • Aria • Aristide • Bat-Levi • A. Batra • Bulast • Carmona • Castillo • Chu-Fong • Cohen • Coron • Donald • Fredericks • Garrett • Thule G'Dok Glemoor • al-Halak • Hemachandra • Holmes • Junior • Katie • Kepler • Kodell • LoPresti • Luttrull • McAvennie • Norrie • Parker • Singh • Singh • Stern • Stewart • Tholav • Tyvan • Varani • Vinson

First officers of the starships Enterprise
Enterprise (NX-01)	Tucker • T'Pol
USS Enterprise (NCC-1701)	Kirk • Shundresh • Simon • Pike • Number One • Spock • Decker • Sulu
USS Enterprise (NCC-1701) (alternate reality)	Spock • Kirk
USS Enterprise (NCC-1701-A)	Spock
USS Enterprise (NCC-1701-B)	Dane • Sulu • Linojj
USS Enterprise (NCC-1701-C)	Carmona • Holmes • al-Halak • Tholav
USS Enterprise (NCC-1701-D)	Riker • Kurn • Stone • Shelby • Data
USS Enterprise (NCC-1701-E)	Riker • Madden • Worf
USS Enterprise (NCC-1701-F) (STO alternate reality)	Winters
ISS Enterprise (NX-01)	Archer
ISS Enterprise (NCC-1701)	Kirk • Spock • Scott • Decker • Riley
ISS Enterprise (NCC-1701-D)	Riker
ISS Enterprise (NCC-1701-E)	Riker • Lore