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The Founders made their homeworld on a rogue planet in the Omarion Nebula. In 2371, Odo experienced a yearning to go to the Omarion Nebula, where he first met other Changelings. (DS9 episodes: "The Search", "The Search, Part II")
In 2371, a joint fleet was launched by the Cardassian Obsidian Order and the Romulan Tal Shiar to eliminate the leaders of the Dominion, the Founders, by attacking their homeworld. The combined fleet was destroyed by the Jem'Hadar in what was known as the battle of the Omarion Nebula. The Founders had evacuated the planet as part of their plan to destroy the intelligence agencies. (DS9 episode: "The Die is Cast")