Ophiucus III is the third planet of the Ophiucus system, and was home to a Federation colony in the 23rd century. New Dakar, a city located on the planet, became known for its artists in the late 23rd century. (TOS novel: Crucible: The Fire and the Rose).

In 2266, Harcourt Fenton Mudd saw an opportunity to provide wives for some of the settlers on Ophiucus III. His venture was interrupted by the crew of the USS Enterprise. (TOS episode: "Mudd's Women").