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Ophiucus (or Ophiucus colony) was a settlement in the triple star system 36 Ophiuchi. It was approximately 19.5 light-years from Earth and located in the Beta Quadrant. The colony existed as early as the mid- 22nd century, and served as a destination for Earth trading vessels. (ST reference: Star Charts)

Whether or not it was an early Earth colony is not clear.
See also: Ophiuchus constellation

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