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In 2372, Quark had an appointment to see Orpax while he was on Ferenginar. Orpax diagnosed him with Dorek Syndrome and gave him a week to live at most. Orpax later contacted Julian Bashir on Deep Space 9 and asked him to tell Quark he was not dying. Quark was extremely pleased, as it meant he could sue Orpax for malpractice. Quark later discovered Orpax had been bribed by Brunt to tell him he was dying. (DS9 episode: "Body Parts", DS9 novel: Ferenginar: Satisfaction is Not Guaranteed)
In 2376, Orpax was treating Leeta while she was pregnant with her and Rom's child Bena. Ishka was wary of them using Orpax as he misdiagnosed Quark four years earlier. (DS9 novel: Ferenginar: Satisfaction is Not Guaranteed)