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Ostenex-D is a medication used to slow the process of loss of bone density.
In 2364, Elias Vaughn was put on a regimen of Ostenex-D. By 2376, Ostenex-D had stopped working for him and the density of Vaughn's bones was decreasing. Learning this from a medical physical, Girani Semna changed his medication from Ostenex-D to Ostenex-E. (DS9 - Worlds of Star Trek: Deep Space Nine novel: Bajor: Fragments and Omens)