Our Lady of Significant Mercy Hospital ("Mercy Hospital" for short) was a medical facility in the city of New Samarkand on Alpha Centauri.

In 2381, following the Borg Invasion that year, fights over medication at Mercy Hospital escalated into rioting, looting, and violence. Mercy Hospital's trauma center was forced to close, and victims were sent to nearby Archer University Hospital instead. (ST novel: A Singular Destiny)