The Presidential Chief of Staff is the individual in the Federation government responsible for organizing and running the office of the President of the United Federation of Planets and the President's staff. The Presidential Chief of Staff serves a chief conselor to the President and has high security clearance, and broad authority over Palais de la Concorde staff members serving the President and the administration. (A Time to Kill, Articles of the Federation)

Presidential Chiefs of Staff
	Vilashrel th'Rithsiria • Penda Ubuntu • Emra Sil • Koll Azernal • Esperanza Piñiero

An unnamed Denobulan served as chief of staff to President Gan Laikan in 2313. (TNG eBook: Slings and Arrows: Enterprises of Great Pitch and Moment)