Quadrant 4 (or Quadrant IV) is a region of space within Federation territory, a treaty boundary quadrant that comprised almost a quarter of the explored space of the Federation in the 22nd and 23rd centuries. This quadrant was divided into two subquadrants, Quadrant 4 North and Quadrant 4 South. (ST reference: Maps)

The Federation starship USS Enterprise was patrolling Quadrant IV on stardate 2314.6, in the 2260s decade, when it received a distress call from planet Terrellian II. (TOS comic: "The Empire Man")

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