A quantum resonance signature is a specific measurement that exists for all forms of matter.

In the year 2370, Worf travelled through alternate realities, where the Data of one of them discovered Worf's quantum resonance signature was different to their own and thus he was not from their reality. (TNG episode: "Parallels")

Data's discovery would later enable Starfleet to differentiate people from the mirror universe. In 2377, when Julian Bashir ran the alternate Iliana Ghemor's signature through a database, the only match was that of the alternate Bareil Antos. Elias Vaughn hoped that a quantum resonance signature could expose Iliana Ghemor herself. (DS9 novels: Fearful Symmetry, The Soul Key)

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