Retnox 5 was a drug used in Humans in the late 24th century to treat failing organs. Dr. Bart Faulwell was allergic to Retnox 5, which limited treatment options when, in 2377, his pancreas, spleen and a kidney were destroyed by an old Disruptor booby trap in the city of Stratos. (CoE eBook: Signs from Heaven)

A previous SCE story, Blackout, established that Faulwell was allergic to the similar-sounding Retlax Five as a youth in the 2330s. Retnox 5 may be a more advanced version of the older drug. Retnox 5 might also be related to Retinax 5.