Rodriguez could refer to:
- People:
- Rodriguez (Enterprise), a crewman aboard the Enterprise NX-01
- Rodriguez (Captain), captain of the USS Yorkshire
- Rodriguez (cadet), a cadet at the Academy when Kirk was there
- Rodriguez (USS Enterprise-D), a security officer of the USS Enterprise-D in 2368
- Ariana Rodriguez, an imaginary person of Cestus III
- Armando Rodriguez, a follower of Khan Noonien Singh
- Ernesta Rodriguez, captain of the USS Gibraltar in the early 24th century
- Esteban Rodriguez, a science officer of the USS Enterprise in the 2260s, and captain of the USS Agamemnon in the early 24th century
- Octavio Rodriguez, one of the crew of the USS Niwen in the 2280s
- Sasha Rodriguez, a helm officer of the USS Lovell in the 2260s
- Real-life topics:
- John Rodriguez, author of Captain Kirk's Guide to Women
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