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The Ryol were a Delta Quadrant species who had strived for perfection using either genetic or cybernetic research, but had ultimately devastated their civilization.

While talking to Roberta Lincoln in 1974, Gary Seven listed the Ryol and several other species who had attempted to create a "superior" version of themselves and had failed. (TOS novel: The Rise and Fall of Khan Noonien Singh, Volume 1)

The crew of the USS Voyager encountered the Ryol in 2373. (VOY novel: The Black Shore)

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