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Scipio may refer to:
- Scipio, a Romulan Centurion-class flagship.
- Scipio, a Romulan Cetratus-class bomber.
- Scipio, a Romulan Gladius-class fighter.
- Scipio, a Romulan Centurion-class support frigate.
- Scipio, a Romulan Securis-class missile cruiser.
- USS Scipio (NCC-553), a Federation Saladin-class starship.
- USS Scipio (NCC-4352), a Federation Larson-class starship.