For Miles O'Brien's 20th century ancestor, see: Sean Aloysius O'Brien

Sean O'Brien was a male Human in the 24th century, and uncle of Miles Edward O'Brien. Sean O'Brien owned a small bar on Alpha Narnia VII, a planet with some of the most beautiful women in the galaxy. O'Brien's bar regularly hosted a "ladies' night." Chief O'Brien selected his Uncle Sean as the person he would most like to trade places with in the universe. (TNG comic: "The Lesson")

Sean's last name is assumed, as it is not given in the story.