Sector 22093 was a region of Federation space, presumable between the Azure Nebula and the planet Andor. The USS Malinche engaged six Borg cubes in sector 22093 during the Borg Invasion of 2381, and was destroyed, with the loss of all hands.

As of stardate 58222.9, Starfleet Command generated two lists of casualties confirmed killed in sector 22093: "Casualty Report 92792382 Alpha" and "Casualty Report 92792382 Baker". (ST novel: A Singular Destiny)