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Sentinel may refer to:
- Prime reality
- USS Sentinel (Miranda class), a Miranda-class starship.
- USS Sentinel (NCC-68455), an Akira-class starship.
- USS Sentinel (NCC-1733-B), a Sovereign-class starship.
- TDS Sentinel, a Trill starship.
- Sentinel-class, a class of Starfleet cruiser in use in the early 25th century
- USS Sentinel (NCC-95792), lead ship of the Sentinel-class
- Alternate reality
- USS Sentinel (Arbiter class), an Arbiter-class missile cruiser.
- USS Sentinel (Constitution class), a Constitution-class flagship.
- USS Sentinel (Defender class), a Defender-class bomber.
- USS Sentinel (Guardian class), a Guardian-class support frigate.
- USS Sentinel (Interceptor class), an Interceptor-class fighter.