Sergane was a star system located in the Federation in the Alpha or the Beta Quadrant.

Its system was home to a number of planets. Sergane III, or Morales, was the only Class M world. It was the homeworld of the Morali, as well as home to an Orion Colony, and was later occupied by Starfleet forces (FASA RPG module: The Orions: Book of Common Knowledge).