A time traveling Ferengi stole the Mona Lisa painting in the 19th century. Another person from the future, disguised in an outfit very much like that of Holmes, gave chase. (Last Unicorn RPG module: All Our Yesterdays: The Time Travel Sourcebook)
When Leonard McCoy entered Starfleet Medical School in 2245, he gained the nickname "Sherlock McCoy" because he could deduce data on a person's lifestyle and interests from pure visual observation. (TOS novel: The Better Man)
Holmes coined the phrase "If you eliminate the impossible, whatever remains – however improbable – must be the truth." In 2293, Spock quoted this, attributing it to an ancestor of his. (TOS movie: Star Trek VI: The Undiscovered Country)
- Spock's statement has been interpreted by some fans as an indication that Sherlock Holmes existed as a real person in the Star Trek universe; however, he may have simply been stating that Arthur Conan Doyle was one of his ancestors.
William T. Riker recommended Doyle's Holmes stories to Data in 2364. (TNG episode: "Lonely Among Us") Data and Geordi La Forge were fond of recreating Holmesian adventures in the USS Enterprise's holodecks. (TNG episodes: "Elementary, Dear Data", "Ship in a Bottle")