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In the mirror universe, Sigma Iotia II was the second planet planet of the Sigma Iotia system star system, located within the space of the Terran Empire in the Beta Quadrant. It was the homeworld of a humanoid race called the Iotians. (Decipher RPG modules: Worlds, Through a Glass, Darkly)
After that, the planet became one large social engineering experiment conducted by the Empire's Bureau of Interstellar Hegemony. Its sociologists introduced various other texts from Earth's 20th century to specific populations on the surface, letting them play themselves out among the population. Eventually, gangs of Iotians adopted strange interpretations of different elements from Earth's dark past and they battled for control. Here, Einstein-like mad scientists confronted totalitarian dictators similar to Stalin, and paranoid versions of Emperor Oswald monitored the activities of Jimmy Carter-like cyborgs. (Decipher RPG module: Through a Glass, Darkly)
In 2277, Oxmyx was the Governor of Sigma Iotia II. That year, he was one of many witnesses of Empress Hoshi Sato III's disintegration using the Tantalus field and the immediate proclamation of Grand Admiral Spock of the Imperial Starfleet as Emperor. (TOS - Mirror Universe novel: The Sorrows of Empire)