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A slug is a type of shellless mollusk found on many planets.
Trill symbionts bore a certain resemblance to slugs, this comparison could be used in friendly conversation, however it could also be taken as an insult; In 2370 when Julian Bashir was describing Hortas to Jadzia Dax he described them as an "oversized slug made out of molten rock" which Dax took badly. Later when the two were at Quark's Kira Nerys stormed in and rebuked Bashir, once she departed Bashir noted that for a second he was worried she was going to slug him, again managing to insult Dax.