Starbase 16 was a Federation starbase that was operational by the mid-23rd century, located near the Tycho star system. (TOS - My Brother's Keeper novel: Constitution)

In 2257, Lieutenant James T. Kirk had the USS Farragut divert to Starbase 16 for repairs following the death of 200 crewmembers after the encounter with a dikironium cloud creature. (TOS - My Brother's Keeper novel: Constitution)

In an alternate timeline, the USS Enterprise docked at Starbase 16 for shore leave in 2269, after successfully stopping a second Federation-Klingon war. (TOS novel: Spock Must Die!)

In 2269, the Great Starship Race to Gullrey was launched from Starbase 16. Following the race, the Enterprise docked at the base for structural repair following a high-warp pursuit of the ChR Red Talon. (TOS novel: The Great Starship Race)

In 2279, the Belle Terre Colonial Expedition was also launched from Starbase 16, with the Enterprise leading a large group of colonization vessels to Occult IV in Cluster Z-80. (TOS - New Earth novel: Wagon Train to the Stars)

Federation starbases
Starbases	1 • 2 • 3 • 4 • 5 • 6 • 7 • 8 • 9 • 10 • 11 • 12 • 13 • 14 • 15 • 16 • 17 • 18 • 19 • 20 • 21 • 22 • 23 • 24 • 25 • 25-Alpha • 26 • 27 • 28 • 29 • 30 • 31 • 32 • 33 • 34 • 35 • 36 • 37 • 39-Sierra • 40 • 41 • 42 • 43 • 44 • 45 • 46 • 47 • 47-Vanguard • 49 • 50 • 51 • 52 • 53 • 55 • 56 • 58 • 61 • 62 • 63 • 64 • 65 • 67 • 68 • 69 • 72 • 73 • 74 • 75 • 77 • 80 • 81 • 82 • 83 • 84 • 85 • 86 • 87 • 88 • 90 • 92 • 93 • 96 • 97 • 99 • 102 • 103 • 104 • 105 • 106 • 108 • 112 • 113 • 114 • 117 • 118 • 121 • 122 • 123 • 129 • 133 • 134 • 137 • 152 • 153 • 157 • 162 • 172 • 173 • 174 • 176 • 178 • 179 • 180 • 182 • 185 • 189 • 193 • 200 • 201 • 209 • 210 • 211 • 212 • 214 • 218 • 219 • 220 • 223 • 227 • 231 • 234 • 235 • 236 • 237 • 247 • 252 • 257 • 260 • 261 • 262 • 263 • 268 • 277 • 295 • 301 • 303 • 307 • 310 • 311 • 312 • 313 • 314 • 315 • 324 • 325 • 326 • 327 • 328 • 336 • 343 • 344 • 347 • 357 • 371 • 375 • 383 • 401 • 410 • 411 • 412 • 414 • 416 • 419 • 420 • 422 • 434 • 440 • 452 • 473 • 495 • 499 • 505 • 514 • 515 • 521 • 523 • 528 • 585 • 612 • 621 • 623 • 693 • 714 • 718 • 804 • 823 • Earhart • G-6 • Icarus • India • Iridani • Leonov • Magellan • MI-17 • Midway • Montgomery • Neil Armstrong
Deep Space Stations	1 • 2 • 3 • 4 • 5 • 6 • 7 • 8 • 9 • 10 • E-5 • G-6 • K-5 • K-7 • K-8 • K-10 • K-12 • KR-3 • M-20 • M-33