Starbase 25 was a Starfleet starbase in operation in the mid 23rd century. The cone-shaped starbase orbited Dengella II, a Class M planet located at the edge of Federation space. (TOS novel: Allegiance in Exile)
In 2269, the USS Enterprise docked at the starbase for repairs after being attacked at R-775 I by Ascendant missiles. Captain James T. Kirk met Commodore Robert Wesley in the starbase's bar, The Roadhouse, as the USS Lexington was also visiting the base at the time.
- Commodore Cohen, commanding officer (2269)
- Doctor Rellan, chief medical officer (2269)
- Ensign Sean Garcia, nurse (2269)
- Garo, waiter (2269)