For the real-world book, see: Star Trek: Starfleet Survival Guide.

The Starfleet Survival Guide was a reference publication issued to members of Starfleet, consisting of information for surviving a variety of life-threatening scenarios.

The Starfleet Survival Guide included instruction on how to cauterize and suture a severe wound using a standard-issue phaser. Commander Rondon used this technique on Crewman Fabian Stevens when he was wounded in a Breen attack on Lamenda Prime in 2375. (short story: "Field Expediency")

Geordi La Forge remembered reading in the survival guide the tech specifications for the environmental suit and how it could even survive planetfall. (TNG novel: A Time to Sow)

All in-universe references to the Starfleet Survival Guide have come subsequent to the publication of the real-world book by David Mack.