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History and specificsEdit
In 2364, an outbreak of Anchilles fever broke out on the planet. Ligon II was the only planet in the region which was known to have developed a vaccine for the fever, and so the USS Enterprise was dispatched to negotiate for a supply of the vaccine. (TNG episode: "Code of Honor")
In one permutation of the mirror universe in which the Terran Empire survived into the 24th century, Styris IV also suffered an outbreak of the Anchilles fever at the same time as its primary universe counterpart. In this reality, the ISS Enterprise was dispatched to Ligon II to obtain the vaccine by any means necessary. The vaccine was eventually obtained after Captain Jean-Luc Picard ordered that the entire southern continent of Ligon II be bombarded by gamma-fission radiation. (TNG novel: Dark Mirror)