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The Temporal Prime Directive, known as General Order 157, is a principle of Starfleet and the Federation Department of Temporal Investigations that was introduced in 2268, requiring non-interference with the timeline in cases of time travel and temporal displacement. (TNG episode: A Matter of Time)

This term has been used several times on-screen, and in seemingly inconsistent contexts. See Memory Alpha article (link below) for further discussion.

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