Tobacco was a highly addictive, carcinogenic plant that was smoked on Earth until the 21st century. (DS9 episode: "Little Green Men") Tobacco could also be chewed for pleasure. Either medium released into the humanoid bloodstream the habit-inducing drug nicotine (DS9 novel: Antimatter).

Tobacco was still used into the 2260s, and was readily available (in Terran and other varieties) aboard the Orion merchant ship Omari-Ekon. (SCE eBook: Distant Early Warning)