Tri-Rho Nautica is an inhabited Federation star system near the borders with the Gorn Empire, the location of planets Tri-Rho Nautica and Tri-Rho Nautica III.

According to a Starfleet Academy simulator scenario, during a hypothetical Federation-Gorn war, a USS Constitution ship patrolled this vicinity. A freighter was seen warping away, leaving behind two Gorn Cruisers. (TOS video game: Starfleet Academy Starship Bridge Simulator)