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Tri-ox compound is an intravenous medicine which is designed to strengthen the cardiopulmonary system, and is effective in enriching a body of oxygen, and is essential to Humans and humanoids who find themselves in oxygen-poor environments, such as the planet Vulcan. (TOS episode: "Amok Time") Vulcans invented tri-ox to help with pneumonia. (TOS novel: Uhura's Song) It was also used as a treatment for smoke inhalation. (TLE novel: Serpents Among the Ruins)
In 2371, in the mirror universe, Jean-Luc Picard injected himself with a dose of tri-ox before entering the Sakethan burial mounds on New T'Karath. (TNG novel: Glass Empires: "The Worst of Both Worlds")