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The Trill Science Ministry was an institute of higher learning within the Federation that was based in the Trill government. It possessed a similar reputation as the Vulcan Science Academy. It was located on the Trill homeworld.
In the 2370s, the Trill Science Ministry was the expert in the field of subspace spatial anomalies and was experimenting with the development of stable artificially created wormholes. (DS9 episode: "Rejoined")
In 2373, the Science Ministry discovered a method of collapsing the Alpha Quadrant terminus of the Bajoran wormhole without harming the Prophets. Upon learning of the large Dominion invasion fleet heading for the wormhole, Captain Benjamin Sisko ordered the plan to be executed, but it was thwarted by a Changeling posing as Julian Bashir. (DS9 episode: "In Purgatory's Shadow")