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The Trill system is a binary star system in which Trillius Prime, the Trill homeworld, is located. Trill is part of the Kalandra sector in the Alpha Quadrant of the Milky Way Galaxy. (ST reference: Star Charts)
In 2265, Starfleet discovered a comet heading towards Trill just outside the Trill system. The Starfleet team noted that the comet did not match the cometary halo that surrounded the star system. (DS9 - The Lives of Dax short story: "Sins of the Mother")
In the 31st century, Benjamin Sisko sent a starship carrying the Dax symbiont from the Bajoran wormhole to the Trill system to save the symbiont after its host died in the Gamma Quadrant. (ST short story: "The Law of Averages")