The USS Amundsen was a Federation starship in Starfleet service in the 23rd century. It was Galaxy Exploration Command vessel.

Doctor Ernst Metz was a lieutenant on the Amundsen when his secret Adrenalane addiction was discovered. He was arrested and charged with the use of illegal narcotics, his medical license was revoked, and he was allowed to resign from Starfleet. (FASA RPG module: Orion Ruse)

The ship was likely named after polar explorer Roald Amundsen.