- For other uses, see USS Antietam.
- No history is established for this vessel as its name was randomly selected for a cruiser by the game software. The first Armada game misspelled the name as Antietem, but it was corrected in the second game.
In July 2376, the Antietam was assigned to Outpost 40 in orbit of Ba'ku in the Briar Patch. When renegade Son'a attacked the starbase, Ambassador Worf of the USS Avenger took command of the ships stationed at Ba'ku to defend the outpost. (TNG video game: Armada mission: Paradise Revisited)
On Stardate 53551.3 (July 20, 2376), the USS Enterprise-E found the USS Antietam adrift near Starbase 612 following a surprise attack by the Borg Collective. Captain Jean-Luc Picard had away teams transport to the Antietam and the rest of the derelict fleet. The Antietam returned to duty in time to ward off further Borg attacks and destroy their base in the sector. (TNG video game: Armada mission: Dark Omens)
During the Borg invasion in 2381, the Antietam was one of the vessels which amassed at the Azure Nebula to defend against the Borg. The Antietam was present during the assault of over seven thousand Borg cubes, but was able to send out a distress call. (ST - Destiny novel: Mere Mortals)
- The novel only mentions the ship name and does not necessarily establish these are the same vessel.