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For other uses, see USS Appalachia.

The USS Appalachia was a Federation starship in service to Starfleet in the late 24th century, after the loss of the previous USS Appalachia in the year 2375.

In 2376, the Appalachia was docked at Starbase 51 and was undergoing a refit. (DS9 - Mission Gamma novel: Lesser Evil)