The USS Kessler (NCC-65527) was a Federation Starfleet vessel in service in the mid-24th century.

The Kessler assisted in the evacuation of Delta IV after the joint Borg/Cybermen invasion of stardate 45635.2, 2368. (TNG - Assimilation² comic: "Issue 1")

The work of the Enterprise crew and The Doctor and his traveling companions led to the prevention of the Borg/Cyberman alliance, so the events at Delta IV were erased from history beyond the people involved having maintained their memories. TNG - Assimilation² comics: "Assimilation², Issue 6", "Assimilation², Issue 8"

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