The USS Lewis and Clark was a Federation starship that was in Starfleet service in the 24th century.
The Lewis and Clark was destroyed by the Tzenkethi at some point prior to 2362. The destruction of the Lewis and Clark was one of several reasons why Benjamin Sisko had come to fear and despise the Tzenkethi. (ST - Typhon Pact novel: Rough Beasts of Empire)
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